A Rare Encounter: Massive Phyllodes Tumor of the Breast - A Case Report and Comprehensive Review
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Abstract
Phyllodes tumors of the breast, rare fibroepithelial neoplasms, present diagnostic and management challenges due to their diverse presentation and unpredictable behavior. This case report discusses a 47-year-old female presenting with a large right breast mass, initially managed with alternative therapies. Examination revealed a 20x10x10 cm mass, diagnosed as a phyllodes tumor via core needle biopsy. A simple mastectomy was performed, with histological analysis confirming a benign phyllodes tumor. The patient recovered uneventfully and was monitored regularly for six months. This case underscores the importance of differentiating phyllodes tumors from fibroadenomas, advocating for core needle biopsy for accurate diagnosis. Surgical excision with negative margins remains the cornerstone of treatment to mitigate recurrence risks. Comprehensive understanding of the tumor's histopathology, epidemiology, and clinical outcomes is essential for effective management and improved patient prognosis.
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Tan, B. Y., Acs, G., Apple, S. K., Badve, S., Bleiweiss, I. J., Brogi, E., … Tan, P. H. (2015). Phyllodes tumours of the breast: a consensus review. Histopathology, 68(1), 5–21. doi:10.1111/his.12876 .
Macdonald, O. K., Lee, C. M., Tward, J. D., Chappel, C. D., & Gaffney, D. K. (2006). Malignant phyllodes tumor of the female breast. Cancer, 107(9), 2127–2133. doi:10.1002/cncr.22228.
Reinfuss M, Mitus J, Duda K, Stelmach A, Rys J, Smolak K.
Zhang Y, Kleer CG. Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. Arch Pathol Lab Med. 2016 Jul;140(7):665-71.
Reinfuss M, Mitus J, Duda K, Stelmach A, Rys J, Smolak K. The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases. Cancer. 1996;77:910-6.
Salvadori B, Cusumano F, Bo DR, Delledonne V, Grassi M, Rovini D, et al. Surgical treatment of phyllodes tumors of the breast. Cancer. 1989;63:2532-6.
Azzopardi JG. Sarcoma of the breast. In: Bennington J, editor. Problems in Breast Pathology. Philadelphia: WB Saunders Co.; 1979:355-359.
Bernstein L, Deapen D, Ross RK. The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast. Cancer. 1993;71(10):3020–3024.
Spitaleri G, Toesca A, Botteri E, Bottiglieri L, Rotmensz N, Boselli S, et al. Breast phyllodes tumor: A review of literature and a single center retrospective series analysis. Crit Rev OncolHematol. 2013;88:427-36.
Chaney AW, Pollack A, Neese MD, Zagars GK, Pisters PW, Pollock RE, et al. Primary treatment of cystosarcoma phyllodes of the breast. Cancer. 2000;89:1502-11.
Pietruszka M, Barnes L. Cystosarcoma phyllodes: a clinicopathologic analysis of 42 cases. Cancer.1978;41:1974-83.
Rowell MD, Perry RR, Hsiu JG, Barranco SC. Phyllodes tumors. Am J Surg. 1993;165:376-9.
Turalba CI, Mahdi EAM, Ladaga L. Fatal metastatic cysto-sarcoma phyllodes in an adolescent female: Case report and review of treatment approaches. J Surg Oncol. 1986;33:176-81.
Contarini O, Urdaneta LF, Hagan W, Stephenson SE. Cysto-sarcoma Phylloides of the breast: a new therapeutic proposal. Am Surg. 1982;48:157-66.
Bhargav PR, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK. Phyllodes tumour of the breast: Clinicopathological analysis of recurrent vs. non-recurrent cases. Asian J Surg. 2009;32:224-8.
Chao TC, Lo YF, Chen SC, Chen MF. Sonographic features of phyllodes tumors of the breast. Ultrasound Obstet Gynecol. 2002;20:64-71.
Chaney AW, Pollack A, McNeese MD, et al. Primary treatment of cystosarcoma phyllodes of the breast. Cancer. 2000;89(7):1502–1511.
Guillot E, Couturaud B, Reyal F, et al. Management of phyllodes breast tumors. Breast J. 2011;17(2):129–137. doi: 10.1111/j.1524-4741.2010.01045.x.
Carlson RW, Allred DC, Anderson BO, et al. Metastatic breast cancer, version 1.2012: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2012;10(7):821–829.
Zeng S, Zhang X, Yang D, Wang X, Ren G. Effects of adjuvant radiotherapy on borderline and malignant phyllodes tumors: a systematic review and meta-analysis. Mol Clin Oncol. 2015;3(3):663–671. doi: 10.3892/mco.2015.503.
Gnerlich JL, Williams RT, Yao K, Jaskowiak N, Kulkarni SA. Utilization of radiotherapy for malignant phyllodes tumors: analysis of the National Cancer Data Base, 1998-2009. Ann Surg Oncol. 2014;21(4):1222–1230. doi: 10.1245/s10434-013-3395-6.
